bosentan will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a minimize in fentanyl plasma concentrations, not enough efficacy or, quite possibly, growth of a withdrawal syndrome within a client who m… Read More